• KML-29for Inflammatory and Nerve Injury

    KML-29for Inflammatory and Nerve Injury

    AASrawBiochemical Technology Co. Ltd.is an Anabolic Steroids Powder Manufacturer. It was once reorganized by a Shanghai-based Biochemical Engineering Laboratory in 2008. AASraw offers high-quality pharmaceutical goods with purity no less than 98%. AASraw has a complete quality control system for its SOP (Standard Operating Procedure). They always offer all items each at a competitive price, but the minimum order is at 10 gram—or 1 gram for certain special items. AASraw is constantly developing medicinal drugs needed in the medical world. All of the items are developed by 5 Chinese Ph. Doctors who are majored in Chemical Engineering at University of Tulsa, Oklahoma, USA. They always improve the technology constantly for better quality and less impurity.

    KML-29, or the CAS number 1380424-42-9, is one of AASraw’savailable items. KML-29 is used on murine inflammatory and sciatic nerve injury pain models, as well as the diclofenac-induced gastric hemorrhage model, in order to test its effect and potency.The result?KML29 attenuates carrageenan-induced paw edema and completely reverses carrageenan-induced mechanical allodynia. These effects undergotolerance after repeatedadministration of high-dose KML29, which are accompanied by cannabinoid receptor 1 (CB1) receptor desensitization.Furthermore, KML29 partially reversesallodynia in the sciatic nerve injury model and completely preventsdiclofenac-induced gastric hemorrhages.

    Below are the known characteristics of the item.

    KML-29, with gabapentin synergistically produces analgesia in mice. KML-29, showshighly selective and potent monoacylglycerol lipase (MAGL) inhibitor, exhibiting potent inhibition of human, mouse,and rat’s MAGL (IC50 values are 5.9, 15 and 43 nM, respectively). It exhibits no detectable inhibition of FAAH (IC50 > 50000 nM), while potently and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50 = 2.5 nM and >50 μM for 2-AG and AEA respectively). KML-29, has amelting point at 204-206°C, so store it at -20°C temperature to keep it in a good condition. KML-29, still can be used for 2 years if stored properly.

    KML-29,  will be shipped under ambient temperature as non-hazardous chemical. Duration during delivery will have no effect on the quality of the product. It is stable enough for a few weeks during ordinary shipping and time spent in customs. In ordering KML-29, the minimum order is 10 gram. KML-29has no side effect, however, keep it away from eyes, no skin contact, and do not swallow. If either happens, contact a physician immediately. Before buying KML-29, read all of the information about KML-29,  that available on AASraw website.

    AASRaw providesan order through email, and if you have any inquiry about KML-29, you can make an online Skype call with their Customer Services Representative (CSR). You can send an email withthe details of your order and also yourshipping address to them. After you have provided information for the order, then their CSR will reply with an email about the quotation, payment term, tracking number, delivery path,and estimated arrival date. Once you’ve made the payment, then the items will be shipped to your address. It is advisable to read AASraw’s terms of shipping before making an order.


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